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DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE deuterium-labeled-amine SiR-Maleimide is a far-red fluorescent

SKU 65639436696
4.8
USD445.00 USD467.00

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Description

SiR-Maleimide is a far-red fluorescent probe containg maleimide function group for bioconjugation apploications

Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB Synonyms CAS Number Related CAS Molecular Formula C50H66N6O11 Molecular Weight 927

897 Purity (HPLC) >= 95% Solubility DMSO

has enhanced potency in PIK3CA mutant models through a unique mechanism of action

DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE deuterium-labeled-amine SiR-Maleimide is a far-red fluorescentSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing

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