DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan macrophage 08 SMILES CC(=O)N1CCN(CC1)C1=CC=C2C(NCCN)=NC(=NC2=C1)C1(CCCCC1)C1=CC=C(Cl)C=C1 Purity (HPLC)

08 SMILES CC(=O)N1CCN(CC1)C1=CC=C2C(NCCN)=NC(=NC2=C1)C1(CCCCC1)C1=CC=C(Cl)C=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name 6-bromo-1-(methyl-d3)-1H-1

10-tetraacetic acid)

84 SMILES NS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC2=C1NC=C2Cl Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan macrophage 08 SMILES CC(=O)N1CCN(CC1)C1=CC=C2C(NCCN)=NC(=NC2=C1)C1(CCCCC1)C1=CC=C(Cl)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further