DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan payload 066 Purity (HPLC) >= 95%

066 Purity (HPLC) >= 95% Solubility DMSO

Product Name Thalidomide-5'-propargyl-PEG1-OH Synonyms CAS Number n/a Related CAS Molecular Formula C18H16N2O6 Molecular Weight 356

Product Name DOTA-PEG2-C2-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C29H47N7O12 Molecular Weight 685

Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C27H50N8O10 Molecular Weight 646

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan payload 066 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC